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Representation of Bodily Self-Consciousness in the Macaque Brain (2019/9/2)
A recent study published in Proceedings of the National Academy of Sciences (PNAS) demonstrates the neural signals in the monkey’s premotor cortex reflecting the strength of hand illusion and the likelihood of misattributing the illusory hand to oneself, revealing the cortical representation of body bodily self-consciousness. This work was performed by researchers in Dr. WANG Liping’s Lab.
Prof. Mu-ming Poo gave a keynote lecture during the 2019 World AI Conference (2019/9/2)
Prof. Mu-ming Poo gave a keynote lecture during the 2019 World AI Conference, in the Brain-Inspired Artificial Intelligence and Collective Intelligence Forum, which was held at Shanghai Expo Center on August 30th, 2019.
Stochastic Cell Cycle-Entry and Cell State-Dependent Fate Outputs of Injury-Reactivated Tectal Radial Glia in Zebrafish (2019/8/24)
A recent study from Dr. HE Jie’s lab at the Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, CAS, investigated two essential questions of the mechanisms underlying the responses of glia in the injured brain. How do the injury-induced reactivated glia enter the cell cycle?
Expanding C-T Base Editing Toolkit with Diversified Cytidine Deaminases (2019/8/9)
In a study published in Nature Communications, researchers from Dr. QIU Zilong’s lab at the Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences and collaborators from ZhongShan Hospital, Fudan University established new cytosine base editors (CBEs) with diversified cytidine deaminases from lampreys. As compared to existed CBEs, new CBEs displayed more diversified and expanded editing windows, with lower off-target activities. This study provides alternative toolkits for the applications of CBEs in the future.
Active Information Maintenance in Working Memory by a Sensory Cortex (2019/8/2)
A recent study published in eLife demonstrates that the anterior piriform cortex (APC), which is an olfactory sensory cortex, is important for the active information maintenance in working memory. This work was performed by researchers in Dr. LI Chengyu’s Lab at the Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences.
New Mechanism of Auditory Categorization in the Cortical Neuronal Populations (2019/7/8)
A recent study published in Neuron demonstrates that neuronal ensembles in mouse auditory cortex exhibit dynamic changes to facilitate stimulus categorization when the animals are engaged in a perceptual categorization task. This work was performed by researchers in Dr. XU Ninglong’s Lab at the Center for Excellence in Brain Science and Intelligence Technology,CAS.
Dr. Jiulin Du gave an academic report at International Zebrafish Conference on invitation (2019/6/26)
From 12thto 16th , June in 2019, Dr. Jiulin Du was invited to attend the 14th ‘International Zebrafish Conference at Suzhou, China and gave an academic report named ‘Anatomical and functional logic of the locus coeruleus system’ on the conference.
DNA Base Editing Induces Substantial Off-target RNA Mutations and Their Elimination by Mutagenesis (2019/6/10)
In a study published in Nature on June 10, researchers from Dr. YANG Hui’s Lab at the Institute of Neuroscience of the Chinese Academy of Sciences (CAS), and collaborators from the CAS-MPG Partner Institute for Computational Biology of CAS and Sichuan University demonstrated that DNA base editors generated tens of thousands of off-target RNA single nucleotide variants (SNVs) and these off-target SNVs could be eliminated by introducing point mutations to the deaminases.
Acute glaucoma impairs visual acuity towards central visual field in non-human primates (2019/6/9)
A recent study published in EBioMedicine provides new insights into the impact of acute elevations of intraocular pressure (IOP) that occur during the disease Glaucoma. This work, in collaboration with Dr. Xinghuai Sun’s group at the Eye and ENT Hospital of Fudan University, was performed at Dr. Wei Wang’s Lab at the Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, CAS.
Modulatory Roles of Glial Cells in Spontaneous Retinal Waves (2019/6/4)
The researchers from Dr. DU Jiulin’s lab at the Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, found that Müller glial cells (MGCs) participate in and modulate retinal waves via AMPA receptors and glutamate transporters on their own processes respectively, by using in vivo calcium imaging and electrophysiological recording in larval zebrafish.
Identifying a New Target for Therapeutic Intervention to UBE3A-Related Neurodevelopmental Disorders (2019/6/3)
A recent study published in PNAS implicates a critical role of UBE3A-PTPA-PP2A signaling in the pathogenesis of UBE3A-related disorders and suggests a target for therapeutic intervention to Angelman syndrome and autism. This work was performed by researchers in Dr. XIONG Zhiqi’s Lab at the Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Science and Prof. LIAO Lujian’s Lab at East China Normal University.
12th Sino-German Frontiers of Science Symposium 2019 (2019/5/24)
The twelfth Sino-German Frontiers of Science Symposium (SINOGFOS) was held in Lübeck, Germany from May 23 to 26, 2019. German and Chinese young scientists had a cross-disciplinary discussion on six cutting-edging scientific topics including Cell Imaging at the Atomic Resolution, Deep Brain Stimulation, Exoplanet Finding, Genome Editing, Reconstructing Ancient Climates, and Robots and Autonomous Systems. Dr YE Zheng co-chaired this year’s symposium and organized the Deep Brain Stimulation session.
Human Cleaving Embryos Enable Robust Homozygotic Nucleotide Substitutions by Base Editors (2019/5/24)
A recent study published in Genome Biology demonstrated that human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors. This study was performed by researchers in Dr. YANG Hui’s Lab, Dr. CHEN Zijiang’s team and Dr. Shoukhrat Mitalipov’s lab. This work has successfully developed a robust method to remarkably improve base editing efficiency in human cleaving embryos.
Solving the Puzzle: How Neuronal Circuits in the Neocortex Make Causal Contributions to Decision-Making (2019/4/29)
A recent study published in Nature Neuroscience from Dr. XU Ninglong’s lab at the Institute of Neuroscience, Chinese Academy of Sciences, now provided new insights into the functional role of PPC in decision-making. In this study, ZHONG et al. obtained compelling evidence to show that PPC indeed plays an essential role in decision-making under critical conditions that were largely ignored in previous studies. The authors employed a novel behavioral technique in mice combined with precise manipulation and monitoring of neuronal activity in PPC, using optogenetics, chemogenetics and in vivo two-photon imaging.
A Novel Therapeutic Strategy for ALS (2019/4/8)
A study published online in Brain on April 1st has revealed a new cellular mechanism for amyotrophic lateral sclerosis (ALS), suggested a novel therapeutic strategy targeting the RNA degradation pathway, and identified an asthma drug as a potential medication for ALS. This work was mainly conducted by researchers from Dr. XU Jin’s lab at the Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences.
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