ION Quarterly Report
Autumn-Winter 2015
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ISSUE INDEX
Faculty of the season: Dr. ZHOU Jia-wei
TRPC6 specifically inhibits Aβ production
Testicular xenografting shortens reproduction cycle in monkeys
Monitoring of dopamine release in zebrafish larvae
Somatosensory neuron types revealed by single-cell RNA-seq
Neural responses to slow and fast camouflage-breaking motion
ION Mini-symposium on Imaging Neuronal and Circuit Dynamics
Center for Excellence in Brain Science and Intelligence Technology established
Faculty of the season: Dr. ZHOU Jia-wei

Dr. ZHOU Jia-Wei was initially trained as a physician. Drawn by his interests in science, he instead chose the career of an academia, but what drives him has always been the same sense of mission to bring treatments to patients. His research in the last thirty years covered a broad range of topics including neuronal differentiation, glial function, neuroinflammation and dopamine homeostasis, all in efforts to find

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TRPC6 specifically inhibits Aβ production

Alzheimer’s disease (AD) is the most common neurodegenerative disease leading to dementia in the aged. Over-production and accumulation of β-Amyloid (Aβ) peptide is critical for the pathogenesis of AD. Generation of Aβ involves cleavage of amyloid precursor protein (APP) by γ-secretase, a protease known to cleave several substrates,

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Testicular xenografting shortens reproduction cycle in monkeys

Non-human primates (NHP) have become increasingly important animal models for neuroscience research. Recently, breakthroughs in gene editing methods have made site-specific gene-modification in NHP possible. However, the usually long reproduction cycle (~4.5 years) is still a major obstacle for widespread use of gene-modified

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Monitoring of dopamine release in zebrafish larvae

Dopamine is crucial in a broad spectrum of brain functions. Larval zebrafish is transparent and has relatively simple yet highly conserved dopaminergic circuitry, therefore provides an ideal vertebrate model to dissect dopaminergic modulation of neural functions. A recent study by scientists at the Institute of Neuroscience, as reported on Nov. 18th in

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Somatosensory neuron types revealed by single-cell RNA-seq

Neurons are highly heterogeneous. One of the most challenging problems in neuroscience is to define neuronal types. Recently, Dr. ZHANG Xu’s group in the Institute of Neuroscience took a new combinatorial approach to classify somatosensory neurons of the mouse dorsal root ganglion (DRG). This work revealed more neuronal

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Neural responses to slow and fast camouflage-breaking motion

Camouflage, which prevents detection of prey and predators in their natural environments, has long fascinated many branches of scientific investigation. In human society, ideas and knowledge relating to camouflage have also been widely applied to fields such as arts, military technology, industrial synthesis and design.

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ION Mini-symposium on Imaging Neuronal and Circuit Dynamics

The ION Mini-symposium on Imaging Neuronal and Circuit Dynamics was held at the Institute of Neuroscience on December 4th, 2015. This mini-symposium presented the recent developments in cutting edge optical imaging technology and their applications to the most challenging neuroscience problems, which includes simultaneously

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Center for Excellence in Brain Science and Intelligence Technology established

It has been increasingly recognized by neuroscientists across the world that while individual labs can make measurable progress to truly solve the mystery of the brain will eventually require inter-discipline and collaborative team efforts. In a drive to develop institutional mechanisms that facilitate such collaboration, the Chinese Academy

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