ION Quarterly Report
Spring-Summer 2016
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ISSUE INDEX
Faculty of the season: Dr. QIU Zi-long
A dopaminergic-inhibitory neural circuit controls behavior selection in zebrafish larvae
Transgenic monkeys overexpressing human Mecp2 gene exhibit autism-like behaviors
Identification of V2 neuronal receptive fields in awake monkeys
Representation of Pinna illusory and physical rotations in human MST
Distributed representation of curvilinear self-motion in Macaque parietal cortex
Causal link between vertical ZIKV infection and malformation of fetal brain established
Dr. Poo Mu-ming honored by the 2016 Gruber Prize
The 7th academic review and the 8th advisory board meeting held
Faculty of the season: Dr. QIU Zi-long

Autism spectrum disorder (ASD) affects 1 in 68 children in the United States. While many of us are familiar with the stereotyped behavioral deficits portrayed by movie characters of ASD, in reality the neurological underpinnings of this complex developmental brain disorder are far from being clear. Dr. Qiu Zi-long aims to fill these gaps in our knowledge. His group's recent publication in Nature established the world's first transgenic monkey model of ASD, which opens up

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A dopaminergic-inhibitory neural circuit controls behavior selection in zebrafish larvae

Appropriate behavioral responses to ever-changing visual cues in the natural environments are critical for animals' well-being and survival. Although visually evoked behaviors engages the visual processing pathways, many of the animal's actions are selected at the visuomotor transformation stage, where superfluous information

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Transgenic monkeys overexpressing human Mecp2 gene exhibit autism-like behaviors

In a work entitled "Autism-like behaviors and germ-line transmission in transgenic monkeys overexpressing MeCP2" published in Nature, Dr. Qiu's Lab teamed up with the ION Suzhou Facility successfully established a transgenic monkey model of autism. 

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Identification of V2 neuronal receptive fields in awake monkeys

Visual perception relies on processing visual images through hierarchically organized brain regions. A crucial step in understanding visual processing is to characterize the neuronal receptive fields (RFs) at each stage, thereby reveal how visual information are encoded and processed by single neurons at different stages.

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Representation of Pinna illusory and physical rotations in human MST

Visual illusions have fascinated mankind for thousands of years. The Pinna illusion is a striking example of rotary motion perception in the absence of physical motion. When approaching or backing away from concentric rings composed of static rhombi slanted in opposite directions, observers experience vivid illusory counter rotations (Figure 1, left). 

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Distributed representation of curvilinear self-motion in Macaque parietal cortex

In our daily life, complex self-motion trajectories through the environment such as making turns while driving typically contain two independent components: the translation and the rotation of the body/head in space. In our inner ears, the peripheral vestibular system has evolved two sets of organs to specifically encode one of these two motion components: the otoliths detect translations

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Causal link between vertical ZIKV infection and malformation of fetal brain established

Recent outbreak of ZIKV infection in the Americas, in particular Brazil, is accompanied by a marked increase in microcephaly cases in newborns. On the basis of potential threat of ZIKV infection to the development of the central nervous system of fetuses, the World Health Organization declared the danger of ZIKV on pregnancy as a Public Health Emergency of International Concern (PHEIC).

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Dr. Poo Mu-ming honored by the 2016 Gruber Prize

Dr. Poo Mu-ming, director of the Institute of Neuroscience, is honored by the prestigious Gruber Neuroscience Prize this year for his seminal discoveries regarding the molecular and cellular mechanisms underlying synaptic plasticity in the brain.

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The 7th academic review and the 8th advisory board meeting held

The 7th Academic Review of ION PIs were held at the ION from May 30th to June 1st. The committee members present at this review included Profs. Tobias Bonhoeffer (Max Planck Institute of Neurobiology), Nancy Ip (The Hong Kong University of Science and Technology), Lily Jan (University of California at San Francisco), Yuh Nung Jan (University of California at San Francisco),

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